This report reviews the current scientific evidence on the potential benefits and harms of chloroquine and hydroxychloroquine for the prevention or treatment of COVID-19. A total of 17 trials were identified — 14 treatment trials and three prevention trials. The evidence available at this time is limited in both quantity and quality, with some of the studies terminated early due to safety concerns. The current evidence does not support the use of high-dose chloroquine because of concerns of cardiac toxicity and increased lethality relative to low-dose chloroquine. The results of the included studies also do not support the use of hydroxychloroquine for treating patients with mild, moderate, or severe COVID-19, nor does hydroxychloroquine appear to prevent COVID-19 post-exposure.
Link to Report
Chloroquine or Hydroxychloroquine to Prevent or Treat COVID-19 (Updated April 23, 2021)
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