Chloroquine and hydroxychloroquine have been identified as potential treatments for COVID-19, with some clinical trials combining chloroquine or hydroxychloroquine with the antibacterial azithromycin. There is currently no evidence regarding the efficacy of chloroquine or hydroxychloroquine for the prevention of COVID-19. With respect to treating COVID-19, the current evidence related to the clinical efficacy of chloroquine or hydroxychloroquine, used with or without azithromycin, has major limitations, and is associated with inconsistent and uncertain findings. As such, at this time, no conclusions can be made regarding the use of these therapies for the treatment of COVID-19. However, several trials are currently underway, including some in Canada, and it may be expected that more definitive answers will be provided in the future.
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