Ongoing Trials of Plasma-Based Therapies for the Treatment of COVID-19

This report provides information on ongoing randomized controlled trials of intravenous immune globulin and hyperimmune globulin being investigated for the treatment of COVID-19. It will be updated every two weeks. Ongoing trials of convalescent plasma are addressed in separate CADTH reports. Link to Report Ongoing Trials of Plasma-Based Therapies for the Treatment of COVID-19 (Updated […]

Serological Tests for COVID-19

If accurate, antibody-based serology tests may provide information on who has COVID-19 or who has been infected. Health Canada is actively assessing these tests within the expedited access process. However, to date, the performance and role of these tests in clinical settings has not been completely demonstrated. Currently, evidence to confirm that individuals have immunity […]

Ongoing Trials for Novel Vaccines in the Prevention of COVID-19

This report provides information on ongoing clinical trials of novel vaccines being investigated for the prevention of COVID-19. It will be updated every two weeks. Ongoing trials of Bacille Calmette-Guérin (BCG) vaccine are addressed in a separate CADTH report. Link to Report Ongoing Trials for Novel Vaccines in the Prevention of COVID-19 (Updated on July […]

Ongoing Trials for Drugs in the Prevention and Treatment of COVID-19

This report provides information on ongoing randomized controlled trials of drugs being investigated to treat or prevent COVID-19. It will be updated every two weeks. Ongoing trials of vaccines and plasma-based therapies are addressed in separate CADTH reports. Link to Report Ongoing Trials for Drugs in the Prevention and Treatment of COVID-19 (Updated July 3, […]

Gabapentin, Phenobarbital, Diazepam, and Lorazepam for the Treatment of Alcohol Withdrawal: Clinical Effectiveness and Guidelines

During pandemics, such as the COVID-19 pandemic, it can be challenging to offer care to vulnerable populations, especially those experiencing alcohol withdrawal. CADTH conducted a Rapid Response on the clinical effectiveness of using gabapentin, phenobarbital, diazepam, or lorazepam to treat alcohol withdrawal. This report also searched for evidence-based guidelines for treating alcohol withdrawal in the […]

Convalescent Plasma Therapy for the Treatment of COVID-19 : A Review of Clinical Effectiveness

Convalescent plasma (CP) therapy is an intervention where plasma is collected from recovered COVID-19 patients in the hope that the disease-specific antibodies could help the recipient recover from COVID-19. Evidence on the effectiveness of CP therapy for the treatment of COVID-19 is still in the early stages. This report summarizes the current evidence and it […]

Remdesivir: Evidence Review and Appraisal

CADTH conducted a Health Technology Review on remdesivir, an antiviral drug currently being used to treat COVID-19. Presently, remdesivir is not approved in Canada and access to it is limited to clinical trials. Four randomized controlled trials were identified (two completed and two ongoing) in the review; however, due to insufficient published evidence, the potential […]

Virtual Pulmonary Rehabilitation for Respirator Disease or Post-Intensive Care Syndrome: Clinical Effectiveness and Guidelines

As a result of the COVID-19 pandemic, many people are interested in whether health care interventions can be done virtually or remotely. CADTH conducted a Rapid Response regarding virtual pulmonary rehabilitation (programs to improve lung function) for patients with respiratory disease or post-intensive care syndrome (health problems individuals may experience after being in intensive care). […]

Venous Thromboembolism Prophylaxis in Patients Hospitalized With COVID-19

Patients hospitalized with COVID-19, particularly those in intensive care units, are at an increased risk for venous thromboembolism (VTE). CADTH’s Horizon Scan identified seventeen studies reporting on the frequency of VTE in patients hospitalized with COVID-19. The Horizon Scan also summarized Canadian and International guidance regarding the dose and duration of pharmacologic thromboprophylaxis for VTE […]

Influenza Vaccination and Risk of Subsequent Non-Influenza Respiratory Viruses: Safety

This CADTH Rapid Response Report looks at evidence on the safety of influenza vaccination in terms of the risk of contracting subsequent non-influenza respiratory viruses. This information might help inform decisions on the administration of the seasonal flu vaccine during the COVID-19 pandemic. Three non-randomized studies were identified. Two found no association between the influenza […]

Health Technology Update, Issue 27

This issue of Health Technology Update features brief summaries of information on a range of technologies that aim to support the prevention, identification, and management of COVID-19 — from smartphone apps for contact tracing to self-collected sampling for diagnostic testing. These technologies were identified through the CADTH Horizon Scanning Service as topics of potential interest […]

Use of Contact Tracing Apps to Contain COVID-19

The urgency of limiting the spread of COVID-19 remains a significant challenge for many jurisdictions across Canada. The utilization of contact tracing apps is being explored as a public health tool in order to help prevent further spread of the disease by tracking those who have been confirmed or assessed as likely to be carriers […]

What You Should Know About Drug Treatments for COVID-19

CADTH created this handout, intended for the general public, explaining the risks of using unproven drug treatments for COVID-19. The handout also provides information on what to do if someone is experiencing COVID-19 symptoms, tips on how to assess the reliability of health information found on the internet, and a list of reliable websites that […]

Methoxyflurane for Acute Pain: Clinical Effectiveness

CADTH conducted a Rapid Response report to search for evidence on the comparative clinical effectiveness of methoxyflurane versus inhaled nitrous oxide for acute pain, as well as the clinical effectiveness of methoxyflurane for acute pain in pre-hospital or emergency department settings. One systematic review was identified; however, it has not been critically appraised by CADTH. […]

Quick Start: Re-establishing Health Services in Indigenous Communities

These citations related to re-establishing health services in indigenous communities are intended to provide a preliminary quick start to more comprehensive searching or to help frame questions or issues. If you’d like to know more, please contact CADTH via our email address or our requests page. Link to Report Quick Start: Re-establishing Health Services in […]

Quick Start: Moral Distress in Health Care Workers

These citations related to moral distress in health care workers are intended to provide a preliminary quick start to more comprehensive searching or to help frame questions or issues. If you’d like to know more, please contact CADTH via our email address or our requests page Link to Report Quick Start: Moral Distress in Health […]

Quick Start: Laboratory Services and COVID-19

These citations related to laboratory services and COVID-19 are intended to provide a preliminary quick start to more comprehensive searching or to help frame questions or issues. If you’d like to know more, please contact CADTH via our email address or our requests page Link to Report Quick Start: Laboratory Services and COVID-19

Quick Start: Radiology Services and COVID-19

These citations related to radiology services and COVID-19 are intended to provide a preliminary quick start to more comprehensive searching or to help frame questions or issues. If you’d like to know more, please contact CADTH via our email address or our requests page. Link to Report Quick Start: Radiology Services and COVID-19

Quick Start: Pulmonary Auscultation Without Touching or Contamination

These citations related to pulmonary auscultation without touching or contamination are intended to provide a preliminary quick start to more comprehensive searching or to help frame questions or issues. If you’d like to know more, please contact CADTH via our email address or our requests page. Link to Report Quick Start: Pulmonary Auscultation Without Touching […]