Ongoing Trials for Novel Vaccines in the Prevention of COVID-19

This report provides information on ongoing clinical trials of novel vaccines being investigated for the prevention of COVID-19. It will be updated every two weeks. Ongoing trials of Bacille Calmette-Guérin (BCG) vaccine are addressed in a separate CADTH report. Link to Report Ongoing Trials for Novel Vaccines in the Prevention of COVID-19 (Updated on July […]

Quick Start: Aerosol Generating Medical Procedures

These citations related to aerosol generating medical procedures are intended to provide a preliminary quick start to enable more comprehensive searching, or to help frame questions or issues. If you’d like to know more, please contact CADTH by email or our requests page. Link to Report Quick Start: Aerosol Generating Medical Procedures  

Quick Start: Pandemic Staffing Allocation

These citations related to pandemic staffing allocation are intended to provide a preliminary quick start to enable more comprehensive searching, or to help frame questions or issues. If you’d like to know more, please contact CADTH by email or our requests page. Link to Report Quick Start: Pandemic Staffing Allocation

Canada

Government of Canada — COVID-19 Guidance Documents

Government of Canada — Awareness Resources

Public Health Agency of Canada — Information on COVID-19

Public Health Agency of Canada — Information on COVID-19 for Health Professionals

British Columbia

Government of British Columbia — Information on COVID-19 BC Centre for Disease Control — Information on COVID-19 BC Centre for Disease Control — Information on COVID-19 for Health Care Professionals and Public Health Partners

Alberta

Government of Alberta — Information on COVID-19 Alberta Health Services — Information on COVID-19 for Alberta Health Services Staff and Health Professionals Alberta Health Services — Scientific Advisory Group COVID-19 Recommendations

Saskatchewan

Government of Saskatchewan — Information on COVID-19 Government of Saskatchewan — Information on COVID-19 for Health Care Providers

Manitoba

Government of Manitoba — Information on COVID-19 Shared Health Manitoba — COVID-19 Resources for Provincial Health Care Providers and Staff

Ontario

Government of Ontario — Information on COVID-19 Ontario Ministry of Health and Ministry of Long-Term Care — COVID-19 Guidance for the Province’s Health Sector Ontario Health — COVID-19 Health System Response Materials

Quebec

Quebec Ministry of Health and Social Services — Information on COVID-19 (in French) Quebec Ministry of Health and Social Services — COVID-19 Clinical Guidelines (in French)

Nova Scotia

Government of Nova Scotia — Government’s Response to COVID-19 Nova Scotia Health Authority — Updates for Physicians and Nova Scotia Health Authority Staff

Reusing Metered Dose Inhalers in a Health Care Setting: Clinical Effectiveness, Cost-Effectiveness, and Guidelines

CADTH searched for evidence on the safety and cost-effectiveness of re-using the canister portion of metered dose inhalers (MDIs) across multiple patients in a health care setting. CADTH also searched for any evidence-based guidelines on the topic. Three non-randomized studies were identified regarding the safety of reusing the canister portion of MDIs and they are […]

New Brunswick

Government of New Brunswick — Information on COVID-19 New Brunswick Office of the Chief Medical Officer of Health — Information for Health and Allied Health Professionals

Prince Edward Island

Government of Prince Edward Island — Information on COVID-19 Government of Prince Edward Island — Information on COVID-19 for Health Care Workers

Northwest Territories

Government of Northwest Territories — Response to COVID-19 Government of Northwest Territories — Information on COVID-19 for Health and Social Services Professionals

Yukon

Government of Yukon — Information on COVID-19 Government of Yukon — Information on COVID-19 for Health Professionals

Dialysis Modalities for the Treatment of End-Stage Kidney Disease

This summary tool provides an overview of the key findings of a CADTH review of dialysis modalities for the treatment of end-stage kidney disease. The review found that home-based dialysis modalities appear to offer clinical benefits similar to those offered by in-centre hemodialysis. Based on this review, self-care home-based dialysis is recommended for eligible patients. […]

Managed Alcohol Programs for Adults With SARS or COVID-19: Safety and Guidelines

CADTH conducted a Rapid Response report to search for evidence on managed alcohol programs for adults with severe acute respiratory syndrome or COVID-19. CADTH also searched for any evidence-based guidelines on these topics; however, no relevant literature and no evidence-based guidelines were identified. Additional resources of potential interest can be found in an appendix to […]

Disposable Continuous Positive Airway Pressure Devices for Respiratory Distress: Clinical Effectiveness and Guidelines

CADTH conducted a Rapid Response search for evidence on the effectiveness of disposable continuous positive airway pressure (CPAP) devices compared with mechanical CPAP devices for patients in respiratory distress. One non-randomized study was found. This information might be of interest to health care decision-makers when considering the use of CPAP in the treatment of COVID-19. […]

Infrared Temperature Devices for Infectious Disease Screening During Outbreaks: Overview of an ECRI Evidence Assessment

CADTH conducted a Focused Critical Appraisal examining the methodology, scientific rigour, and findings of the ECRI Clinical Evidence Assessment on infrared temperature devices for infectious disease screening during outbreaks. Overall, at the time of the review, there was insufficient evidence to suggest that non-contact infrared temperature screening is effective for detecting infected individuals. Link to […]

Quick Start: Simulators for Expansion of Acute Care for COVID-19

These citations related to simulators for the expansion of acute care for COVID-19 are intended to provide a preliminary quick start to enable more comprehensive searching or to help frame questions or issues. If you’d like to know more, please contact CADTH by email or our requests page. Link to Report Quick Start: Simulators for […]

Medication Administration via Multi-Dose Inhalers and Aerochambers Versus Nebulizers: Clinical Effectiveness

CADTH conducted a Rapid Response report to search for evidence regarding the clinical effectiveness of medication administration via multi-dose inhalers compared to nebulizers. This report may be of interest to health care professionals treating patients with asthma or chronic obstructive pulmonary disease, as the CADTH report found studies with patients experiencing these conditions. Link to […]

Resumption of elective health services amid COVID-19

CADTH has prepared a briefing note that describes the challenges health systems face in making decisions about resuming elective procedures during the COVID-19 pandemic, summarizes some recent guidance on service resumption, and discusses potential implications and long-term considerations for these choices. Link to Report Resumption of elective health services amid COVID-19

Contact Tracing for Potential Exposure to SARS-CoV-2 Virus: Guidelines

CADTH conducted a Rapid Response search for evidence-based guidelines regarding contact tracing for people who have been in contact with a person with a suspected or confirmed diagnosis of the coronavirus disease (COVID-19). No relevant evidence-based guidelines were identified; therefore, no conclusions can be drawn. Note that a list of potentially relevant citations can be […]

Isolation Measures to Prevent COVID-19 Transmission: Clinical Evidence and Guidelines

This Rapid Response review aimed to identify available clinical evidence and evidence-based guidelines regarding home or community isolation for the prevention of COVID-19. The review did not identify any clinical evidence or evidence-based guidelines on this topic. Therefore, no conclusions can be drawn based on this review. The report includes other references of potential interest. […]

Quick Start: Resumption of Surgical Services

These citations related to resumption of surgical services are intended to provide a preliminary quick start to enable more comprehensive searching or to help frame questions or issues. If you’d like to know more, please contact CADTH by email or our requests page. Link to Report Quick Start: Resumption of Surgical Services

Pre-Treatment Mouth Rinses for Dental Patients With Suspected SARS or COVID-19: Clinical Effectiveness and Guidelines

In response to the COVID-19 pandemic, CADTH looked for studies on the clinical effectiveness of using pre-dental treatment mouth rinses for patients with suspected SARS or COVID-19 in order to prevent virus transmission from patients to oral health care providers. The report also looked for evidence-based guidelines for the use of pre-treatment mouth rinses in […]

Digital Stethoscope for Patients with Confirmed or Suspected Infectious Disease: Guidelines

CADTH conducted a Rapid Response report to search for evidence-based guidelines related to the use of digital stethoscopes for pulmonary auscultation in patients with suspected or confirmed infectious disease. No relevant evidence-based guidelines were identified; therefore, no conclusions can be drawn based on this review. Note that a list of other potentially relevant citations can […]

SARS-CoV-2 Longevity on and Transmission via Materials: Evidence

This report reviewed the available literature on the lifespan of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on different materials, as well as its potential for transmission via these materials. One non-randomized study was identified, which reported that SARS-CoV-2 was viable on plastic and stainless steel for up to 72 hours, on copper for up […]

Hand Washing for Health Care Workers to Reduce the Transmission of Infection: Clinical Effectiveness and Guidelines

In response to the COVID-19 pandemic, CADTH looked for studies on hand washing for health care workers to reduce the transmission of infection. One systematic review and one non-randomized study were identified regarding the clinical effectiveness of hand washing with soap and water compared with hand sanitization solutions. Three evidence-based guidelines were identified regarding the […]

Masks During Aerosol Generating ENT Procedures: Clinical Effectiveness and Guidelines

In response to the COVID-19 pandemic, CADTH looked for studies on the effectiveness of masks to protect clinicians and health care workers from hospital-acquired infections during aerosol-generating ear, nose, and throat procedures. The review found no relevant studies or guidelines on this specific topic. Note, however, that all masks for medical use must undergo an […]

Masks During Aerosol-Generating Dental Procedures: Clinical Effectiveness and Guidelines

In response to the COVID-19 pandemic, CADTH looked for studies on the effectiveness of masks to protect dental clinicians from acquired infections during aerosol-generating dental procedures. One non-randomized study on the clinical effectiveness of masks was identified. No relevant evidence-based guidelines on this topic were found. Note, however, that all masks for medical use must […]

Internet-Based Cognitive Behavioural Therapy for Post-Traumatic Stress Disorder

This report provides a comprehensive review of the evidence and recommendations on internet-delivered cognitive behavioural therapy (iCBT) for treating post-traumatic stress disorder (PTSD). The report notes that although there may be a role for iCBT in treating PTSD, more research is needed. This information may be of interest to decision-makers exploring non‒face-to-face mental health care […]

Healthy Aging

This Environmental Scan focuses on interventions promoting healthy aging and preventing frailty in older, community-dwelling adults. The scan is based on a literature review and a survey of Canadian contacts working in this area. This information may be useful to decision-makers considering those at higher risk for severe illness from COVID-19, including older adults. This […]

Internet-Delivered Cognitive Behavioural Therapy for Major Depressive Disorder and Anxiety Disorders: A Health Technology Assessment

This report provides a comprehensive review of the evidence and recommendations on internet-delivered cognitive behavioural therapy (iCBT) for treating depression and anxiety disorders. The review found that iCBT is effective for reducing symptoms of mild-to-moderate major depression and select anxiety disorders, and for improving quality of life. iCBT offered with therapist support is recommended. This […]

An Overview of Clinical Applications of 3-D Printing and Bioprinting

This bulletin describes 3-D printing and bioprinting technologies in use, or being studied for use, in health care. No evidence on 3-D-printed personal protective equipment was found, but the bulletin might still be of interest to decision-makers considering 3-D printing as a solution to equipment shortages. There is currently a lack of high-quality evidence on […]

Non-Manual Room Disinfection Techniques for Infection Prevention in Health Care Facilities: Clinical Effectiveness, Cost-Effectiveness, and Guidelines

This report summarizes the abstracts of studies on non-manual room disinfection methods for preventing hospital-acquired infections. It might be of interest to those making decisions on how to disinfect rooms where COVID-19 patients have been treated. The included studies investigated products and devices that use ultraviolet light, hydrogen peroxide vapour, and copper for room disinfection. […]

Artificial Intelligence in Population and Public Health

This bulletin reviewed clinical applications of artificial intelligence (AI) that may impact the care of patients. It identified some AI programs being explored for use in the diagnosis and/or treatment of mental health disorders. As demand for mental health services may increase as a result of the COVID-19 pandemic, this information may be of interest […]

New Disinfection Technologies to Reduce Health Care-Associated Infections

This bulletin (2017) reviewed five environmental disinfection measures that may supplement standard cleaning and disinfection strategies: blue-violet light disinfection for hospital rooms, a pulsed-xenon UV light disinfection system for hospital rooms, a countertop UV-C light disinfection system for mobile devices, antimicrobial compressed salt for high-touch surfaces, and shark skin-like micropatterned surfaces to reduce bacterial adhesion. […]

Point-of-Care Testing for Influenza

This bulletin describes point-of-care testing for influenza, including the available evidence on specific test devices. The bulletin may be of interest to decision-makers looking for quicker ways to diagnose coronavirus. Link to Report Point-of-Care Testing for Influenza  

Antimicrobial Copper Surfaces for the Reduction of Health Care–Associated Infections in Intensive Care Settings

This report evaluated the evidence for the installation of antimicrobial copper surfaces as an infection control mechanism in health care settings. Limited evidence was found at the time of publication (2015); confirmation of a sustained reduction in infection rates over time and the cost-effectiveness of replacing existing surfaces with antimicrobial copper surfaces in Canadian health […]

Initiatives to Optimize the Utilization of Laboratory Tests

This environmental scan provides information from across Canada and internationally on initiatives to improve patient care and reduce costs through test utilization management. This information may be useful to decision-makers looking at ways to optimize the use of COVID-19 tests. The report notes a lack of publicly available information on such initiatives. Link to Report […]

Aerosol-Generating Procedures and Risk of Transmission of Acute Respiratory Infections: A Systematic Review

The COVID-19 pandemic puts health care workers treating COVID-19 patients at risk of becoming infected themselves. CADTH previously conducted a systematic review to evaluate the evidence for the risk of transmission of acute respiratory infections to health care workers caring for patients undergoing aerosol-generating procedures. Very low-quality evidence suggested that some aerosol-generating procedures were associated […]

Transitioning Long-Term Ventilator-Dependent Patients Out of the Intensive Care Unit

This environmental scan reports on survey responses from nine Canadian long-term ventilator programs. It describes the varied ways the programs assess and address medical and non-medical factors before moving patients out of ICU. It might be of interest to those making decisions regarding the transition of stable COVID-19 patients from ICU ventilators to alternate levels […]

Physical Interventions to Interrupt or Reduce the Spread of Respiratory Viruses — Resource Use Implications: A Systematic Review

CADTH previously conducted a systematic review to evaluate resource use and economic considerations related to physical interventions aimed at interrupting or reducing the spread of respiratory viruses. Such interventions include screening at points of entry, isolation, quarantine, social distancing, barriers, personal protection (e.g., wearing masks, gloves, and gowns), and hand hygiene. This report may be […]