Ongoing Trials for Drugs in the Prevention and Treatment of COVID-19

This report provides information on ongoing randomized controlled trials of drugs being investigated to treat or prevent COVID-19. It will be updated every two weeks. Ongoing trials of vaccines and plasma-based therapies are addressed in separate CADTH reports. Link to Report Ongoing Trials for Drugs in the Prevention and Treatment of COVID-19 (Updated February 19, […]

Tocilizumab and Sarilumab: Evidence Review and Appraisal

Tocilizumab and sarilumab are classified as humanized monoclonal antibodies against the interleukin-6 receptor and are used in rheumatology. CADTH has conducted a Technology Review on tocilizumab and sarilumab for their potential use in managing COVID-19. Link to Report Tocilizumab and Sarilumab: Evidence Review and Appraisal

Remdesivir: Evidence Review and Appraisal

CADTH conducted a Health Technology Review on remdesivir — an antiviral drug currently being used to treat COVID-19. Remdesivir was approved in Canada on July 27, 2020 to treat adults and adolescents with severe symptoms of COVID-19 who have pneumonia and require extra oxygen. Four randomized controlled trials were identified and included in the review. […]

Respiratory Personal Protective Equipment for Female Presenting Individuals

CADTH conducted a Rapid Response Report to search for clinical evidence or evidence-based guidelines regarding the use of respiratory personal protective equipment designed specifically for female presenting individuals during COVID-19. However, no clinical evidence or evidence-based guidelines were identified. References that did not meet the inclusion criteria, but may still be of interest, were included […]

Ivermectin for the Treatment and Prevention of COVID-19

To find effective treatment for COVID-19, researchers have started studying older drugs approved for other infections or diseases. One recent drug of interest is ivermectin, a drug typically used to treat patients with parasitic infections (e.g., roundworm). This report looks at the evidence regarding ivermectin to treat patients with COVID-19 infections. While some lab studies […]

Saliva-Based Testing as an Alternative to Traditional COVID-19 Testing Techniques

This newsletter article provides an overview of saliva-based testing in the context of the COVID-19 pandemic. The article briefly explores the different types of COVID-19 tests, the potential advantages of using saliva samples for testing, the clinical evidence, and the current practice in Canada. Link to Report Saliva-Based Testing as an Alternative to Traditional COVID-19 […]

Respirator Device Fit for Individuals With Facial Hair

A properly fitted respirator device (e.g., N95 masks) is an important piece of personal protective equipment. With the COVID-19 pandemic, there is greater interest in how well filtering respirator devices fit when a person has facial hair — like a beard, moustache, or sideburns. This report looks at the evidence regarding facial hair and respirator […]

Saliva-Based Testing as an Alternative to Traditional COVID-19 Testing Techniques

This newsletter article provides an overview of saliva-based testing in the context of the COVID-19 pandemic. The article briefly explores the different types of COVID-19 tests, the potential advantages of using saliva samples for testing, the clinical evidence, and the current practice in Canada. Link to Report Saliva-Based Testing as an Alternative to Traditional COVID-19 […]

Bamlanivimab Implementation Panel

Bamlanivimab is authorized by Health Canada (in accordance with the Interim Order Respecting the Importation, Sale and Advertising of Drugs for Use in Relation to COVID-19) to treat adult and pediatric patients 12 years of age or older with mild to moderate COVID-19, who weigh at least 40 kg and are at high risk of […]

Bamlanivimab in the Treatment of Outpatients With COVID-19: A Critical Appraisal of an Interim Analysis of the BLAZE-1 Trial

CADTH conducted a Health Technology Review on bamlanivimab, a drug authorized (with terms and conditions) by Health Canada to treat adult and pediatric patients 12 years of age or older with mild to moderate COVID-19, who weigh at least 40 kg and are at high risk of progressing to severe COVID-19 illness and/or hospitalization. The […]

What You Should Know About Drug Treatments for COVID-19

CADTH created this handout, intended for the general public, explaining the risks of using unproven drug treatments for COVID-19. The handout also provides information on what to do if someone is experiencing COVID-19 symptoms, tips on how to assess the reliability of health information found on the internet, and a list of reliable websites that […]

Ongoing Trials of Plasma-Based Therapies for the Treatment of COVID-19

This report provides information on ongoing randomized controlled trials of intravenous immune globulin and hyperimmune globulin that are being investigated for the management of COVID-19. It will be updated every month. Ongoing trials of convalescent plasma are addressed in separate CADTH reports Link to Report Ongoing Trials of Plasma-Based Therapies for the Treatment of COVID-19 […]

COVID-19 mRNA Vaccines for People With Cancer

The first two vaccines (both messenger ribonucleic acid — mRNA — vaccines) for the prevention of COVID-19 disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been authorized for emergency use. People with cancer are at a higher risk for serious illness resulting from COVID-19, but were not specifically included in the trials […]

Rapid Point-of-Care Testing for COVID-19

This CADTH Horizon Scan describes how rapid point-of-care screening tests for COVID-19 are being used in Canada and internationally. It also reports on evidence regarding their effectiveness on COVID-19 transmission (no studies identified) and performance. The scan identifies guidance documents that provide suggestions for use in specific settings and populations. Link to Report Rapid Point-of-Care […]

Serological Tests for COVID-19

If accurate, antibody-based serology tests may provide information on who has COVID-19 or who has been infected. Health Canada is actively assessing these tests within the expedited access process. However, to date, the performance and role of these tests in clinical settings has not been completely demonstrated. Currently, evidence to confirm that individuals have immunity […]

Virus-neutralizing monoclonal antibodies against SARS-CoV-2

This Horizon Scan explores what we know about virus-neutralizing monoclonal antibodies, their mechanism of action and how they are administered, and which virus-neutralizing monoclonal antibodies are in clinical development for SARS-CoV-2 infection. Link to Report CADTH Emerging Health Technology for COVID-19: Virus-Neutralizing Monoclonal Antibodies Against SARS-CoV-2  

COVID-19 Testing: A Summary of Testing Methods

This report provides an overview of testing methods for COVID-19. A description of published clinical evidence and important considerations related to the potential implementation of these tests are provided. As demands for testing during the pandemic increases, this information may be of interest to health care decision-makers interested in learning more about the availability and […]

COVID-19 Impact on Intimate Partner Violence and Child Maltreatment

This report provides an overview of the evidence regarding the impact of COVID-19 and related restrictions on intimate partner violence and child maltreatment. The report also includes information on risk factors for violence, access to support for those at risk, and measures to mitigate the risk of intimate partner violence and child maltreatment during this […]

Quick Start: Public Health Interventions for the Prevention of COVID-19 in Schools: Guidelines

These citations related to public health interventions and prevention of COVID-19 in schools are intended to provide a preliminary quick start to enable more comprehensive searching, or to help frame questions or issues. Overall, three evidence-based guidelines were identified. If you would like to know more, please contact CADTH by email or via our requests […]

Convalescent Plasma Therapy for the Treatment of COVID-19 : A Review of Clinical Effectiveness

Convalescent plasma (CP) therapy is an intervention where plasma is collected from recovered COVID-19 patients in the hope that the disease-specific antibodies could help the recipient recover from COVID-19. Evidence on the effectiveness of CP therapy for the treatment of COVID-19 is still in the early stages. This report summarizes the current evidence and it […]

Protective Eyewear for Health Care Workers: Clinical Effectiveness and Guidelines

This CADTH Rapid Response Report looks at evidence and recommendations regarding the clinical effectiveness of protective eyewear for health care workers caring for patients with suspected or confirmed respiratory tract infections. No relevant literature or evidence-based guidelines were identified; however, articles of potential interest are provided in the appendix. Link to Report Protective Eyewear for […]

Synopsis for the Resumption of Colorectal and Cervical Cancer Screening during the Covid-19 pandemic

Non-urgent cancer treatment procedures were delayed or postponed as a result of the COVID-19 pandemic. There is considerable concern that when screening programs do resume, there may be a backlog of screen-positive patients who may be diagnosed at more advanced stages. CADTH undertook a literature search of scientific evidence, clinical guidelines, recommendations, national standards, and […]

Synopsis of Reference Search Results for Topics in Long-Term Care

The COVID-19 pandemic has been challenging for those living and working in long-term care (LTC) facilities. There has been uncertainty related to managing visitors to LTC, the psychological and social impact of isolation for LTC residents, and how best to support LTC staff during this pandemic. To help support health care decision-makers facing these issues, […]

Systemic Corticosteroids for the Management of COVID-19: A Review of Clinical Effectiveness

There are currently multiple management strategies for COVID-19, including the use of corticosteroids. Preliminary results have found that corticosteroids may lower mortality among severe and critical COVID-19 cases and is recommended for use by those on respiratory support. CADTH has conducted a review to summarize the current clinical evidence on systemic corticosteroids for the management […]

Rapid Point-of-Care Antigen Testing for SARS-CoV-2 Infection

This newsletter explores recent developments in testing for COVID-19. Testing for COVID-19 infection is important to stopping spread of the virus. There is also a need for tests that can quickly provide results. Evidence related to rapid point-of-care antigen testing — such as current practice, availability in Canada, cost, and safety — are summarized in […]

Temperature, Humidity, and COVID-19: Evidence

These citations related to weather and COVID-19 infection are intended to provide a preliminary quick start to enable more comprehensive searching, or to help frame questions or issues.If you would like to know more, please contact CADTH by email or our requests page. Link to Report Temperature, Humidity, and COVID-19: Evidence  

Ventilation and Perfusion Imaging for the Diagnosis of Pulmonary Embolisms During the COVID-19 Pandemic: A Review of Safety and Guidelines

This Rapid Response review looked for clinical evidence and evidence-based guidelines on ventilation-perfusion imaging for diagnosing pulmonary embolism during the COVID-19 pandemic. Because the procedure often induces coughing in patients, there are concerns about its potential role in transmitting COVID-19 infection from patients to health care providers. However, no relevant evidence or evidence-based guidelines were […]

Wearable Devices for Monitoring and Detecting COVID-19 Symptoms

Wearable devices — such as watches, arm bands, and patches — may help reduce the spread of COVID-19. Wearable technologies could improve early symptom detection, especially through close monitoring of contacts . They may also safely monitor patients from a distance and limit health care worker exposure. This bulletin explores different wearable technologies in the […]

Non-Invasive Ventilation With Helmets for Acute Respiratory Distress Due to COVID-19

This Health Technology Update newsletter describes patient helmets, also known as “helmet masks,” and their potential use in COVID-19 infection control. These helmets are designed to reduce the risk of COVID-19 transmission from infected patients to health care providers and other patients. The newsletter provides a background to the technology, target populations, cost and availability, […]

Heating, Ventilation, and Air Conditioning Systems in Public Spaces

This report reviews evidence related to airflow transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the risk associated with the use of heating, ventilation and air conditioning (HVAC) systems. A targeted literature review along with a multidisciplinary expert panel discussion were the primary approaches to examine the evidence. More robust, published, peer-reviewed evidence is […]

Triage Tools and Management Algorithms for Colorectal Cancer Screening: Guidelines

CADTH conducted a Rapid Response Report to search for evidence-based guidelines regarding the use of stool-based screening tests, screening triage tools, or management algorithms for colorectal cancer screening. However, no relevant evidence-based guidelines were identified in these searches. Link to Report Triage Tools and Management Algorithms for Colorectal Cancer Screening: Guidelines

Tocilizumab for the Treatment and Prevention of COVID-19: A Review of Clinical Effectiveness

Tocilizumab (TCZ), a recombinant humanized monoclonal antibody, used for severe rheumatoid arthritis and life-threatening cytochrome release syndrome, may be a potential treatment option for COVID-19 infection. Patients with severe COVID-19 infection showed an increase in pro-inflammatory cytokines; hence, it was thought that blocking the receptor of these agents may reduce the inflammatory response to COVID-19. […]

CADTH Emerging Health Technology for COVID-19: Sarilumab

Sarilumab is an interleukin-6 receptor antagonist indicated, in Canada, for rheumatoid arthritis and has been identified as a potential option for treating COVID-19. Two published studies were identified in the CADTH Horizon Scan that evaluated the efficacy and safety of sarilumab for the treatment of COVID-19. Link to Report CADTH Emerging Health Technology for COVID-19: […]

Resumption of Routine Cancer Screening during the COVID-19 Pandemic : Guidelines

CADTH conducted a Rapid Response Report to search for evidence-based guidelines regarding resuming routine cancer screening during the COVID-19 pandemic. One evidence-based guideline from the American Gastroenterological Association (AGA) Institute was identified. However, no evidence-based guidelines that were either broader in scope, or specific to other fields, were identified. Link to Report Resumption of Routine […]

What You Should Know About Dexamethasone for Treating COVID-19

This tool provides general information about the drug dexamethasone, its past uses, and new evidence for dexamethasone as a potential treatment for COVID-19. The results from the dexamethasone arm of the RECOVERY trial are provided, together with the current Canadian recommendations for its use in treating COVID-19. Link to Tool What You Should Know About […]

Lopinavir-Ritonavir for the Treatment and Prevention of COVID-19: A Review of Clinical Effectiveness

HIV medications lopinavir and ritonavir (LPVR), in combination, are currently being investigated as a proposed COVID-19 treatment. The potential mechanism of action of LPVR is that it may disrupt the replication and spread of the severe acute respiratory syndrome coronavirus 2 — or SARS-CoV-2 — within the body. However, there is uncertainty around the clinical […]

Chloroquine or Hydroxychloroquine to Prevent or Treat COVID-19

This report reviews the current scientific evidence on the potential benefits and harms of chloroquine and hydroxychloroquine for the prevention or treatment of COVID-19. A total of four trials were identified — three treatment trials and one prevention trial. The evidence available at this time is limited in both quantity and quality, with some of […]

Virtual Waiting Rooms

The “CADTH Work in Progress” page on the CADTH COVID-19 website is updated regularly. Please be advised that there may be overlap between when a new report is posted online and when the section is updated.

Gabapentin, Phenobarbital, Diazepam, and Lorazepam for the Treatment of Alcohol Withdrawal: Clinical Effectiveness and Guidelines

During pandemics, such as the COVID-19 pandemic, it can be challenging to offer care to vulnerable populations, especially those experiencing alcohol withdrawal. CADTH conducted a Rapid Response on the clinical effectiveness of using gabapentin, phenobarbital, diazepam, or lorazepam to treat alcohol withdrawal. This report also searched for evidence-based guidelines for treating alcohol withdrawal in the […]

Virtual Pulmonary Rehabilitation for Respirator Disease or Post-Intensive Care Syndrome: Clinical Effectiveness and Guidelines

As a result of the COVID-19 pandemic, many people are interested in whether health care interventions can be done virtually or remotely. CADTH conducted a Rapid Response regarding virtual pulmonary rehabilitation (programs to improve lung function) for patients with respiratory disease or post-intensive care syndrome (health problems individuals may experience after being in intensive care). […]

Venous Thromboembolism Prophylaxis in Patients Hospitalized With COVID-19

Patients hospitalized with COVID-19, particularly those in intensive care units, are at an increased risk for venous thromboembolism (VTE). CADTH’s Horizon Scan identified seventeen studies reporting on the frequency of VTE in patients hospitalized with COVID-19. The Horizon Scan also summarized Canadian and International guidance regarding the dose and duration of pharmacologic thromboprophylaxis for VTE […]

Influenza Vaccination and Risk of Subsequent Non-Influenza Respiratory Viruses: Safety

This CADTH Rapid Response Report looks at evidence on the safety of influenza vaccination in terms of the risk of contracting subsequent non-influenza respiratory viruses. This information might help inform decisions on the administration of the seasonal flu vaccine during the COVID-19 pandemic. Three non-randomized studies were identified. Two found no association between the influenza […]

Health Technology Update, Issue 27

This issue of Health Technology Update features brief summaries of information on a range of technologies that aim to support the prevention, identification, and management of COVID-19 — from smartphone apps for contact tracing to self-collected sampling for diagnostic testing. These technologies were identified through the CADTH Horizon Scanning Service as topics of potential interest […]

Use of Contact Tracing Apps to Contain COVID-19

The urgency of limiting the spread of COVID-19 remains a significant challenge for many jurisdictions across Canada. The utilization of contact tracing apps is being explored as a public health tool in order to help prevent further spread of the disease by tracking those who have been confirmed or assessed as likely to be carriers […]

Quick Start: Mobile COVID-19 Testing in Industry

These citations related to mobile testing in industry are intended to provide a preliminary quick start to more comprehensive searching or to help frame questions or issues. If you’d like to know more, please contact CADTH via our email address or our requests page. Link to Report Quick Start: Mobile COVID-19 Testing in Industry

Methoxyflurane for Acute Pain: Clinical Effectiveness

CADTH conducted a Rapid Response report to search for evidence on the comparative clinical effectiveness of methoxyflurane versus inhaled nitrous oxide for acute pain, as well as the clinical effectiveness of methoxyflurane for acute pain in pre-hospital or emergency department settings. One systematic review was identified; however, it has not been critically appraised by CADTH. […]

Personal Protective Equipment for Endoscopy or General Surgery in Patients with Respiratory Infections: Guidelines

CADTH conducted a Rapid Response Report to search for evidence-based guidelines regarding the use of personal protective equipment during endoscopy or general surgery procedures for patients who may have respiratory infections such as COVID-19. Two evidence-based guidelines were identified, with one specifically providing guidance on surgical care during the COVID-19 pandemic. Link to Report Personal […]

Convalescent Plasma Therapy for the Treatment of COVID-19: Clinical Effectiveness

CADTH performed a literature search to find evidence on the clinical effectiveness of convalescent plasma therapy for the treatment of COVID-19. Two non-randomized studies were identified and their abstracts (as well as the links to the full publications) are included in this report; however, CADTH has not critically appraised these studies. Additional information of potential […]

Pulse Oximetry Monitoring in Patients at Risk of Hypoxia: An Ultra-Rapid Review of Clinical Utility and Guidelines

CADTH conducted an ultra-rapid response report to evaluate the clinical utility of pulse oximetry monitoring (including portable pulse oximetry devices) for patients at risk of hypoxia (oxygen deficiency) due to COVID-19. CADTH’s review also searched for any evidence-based guidelines. No evidence specific to COVID-19 was identified; however, four non-randomized studies of patients at risk of […]

Impact of substituting Coumadin lab test results

INESSS’s Position (07-05-2020) Based on the scientific literature available when preparing the report and on the various consultations carried out, and despite a very quick review process, INESSS finds that: There should not be any particular clinical issues in substituting Coumadin® with a generic version of warfarin. Section 21 of the Pharmacy Act shall apply. […]

Testing for COVID-19 in Correctional Facilities: Clinical Effectiveness and Guidelines

CADTH conducted a Rapid Response report to search for evidence on the clinical effectiveness of COVID-19 testing for all new admissions to correctional facilities, as well as the clinical effectiveness of mass testing (i.e., testing everyone within the correctional facility for COVID-19). CADTH also searched for any evidence-based guidelines on these topics. However, no relevant […]

Quick Start: Re-establishing Health Services in Indigenous Communities

These citations related to re-establishing health services in indigenous communities are intended to provide a preliminary quick start to more comprehensive searching or to help frame questions or issues. If you’d like to know more, please contact CADTH via our email address or our requests page. Link to Report Quick Start: Re-establishing Health Services in […]

Quick Start: Moral Distress in Health Care Workers

These citations related to moral distress in health care workers are intended to provide a preliminary quick start to more comprehensive searching or to help frame questions or issues. If you’d like to know more, please contact CADTH via our email address or our requests page Link to Report Quick Start: Moral Distress in Health […]

Quick Start: Laboratory Services and COVID-19

These citations related to laboratory services and COVID-19 are intended to provide a preliminary quick start to more comprehensive searching or to help frame questions or issues. If you’d like to know more, please contact CADTH via our email address or our requests page Link to Report Quick Start: Laboratory Services and COVID-19

Plastic or Reusable Aerochambers in Multi-Dose Inhalers: Clinical Effectiveness and Guidelines

CADTH created a Rapid Response report that included a search for evidence regarding the clinical effectiveness of plastic or reusable aerochambers in multi-dose inhalers for patients requiring medication administration, as well as any evidence-based guidelines on the topic. However, no relevant literature or evidence-based guidelines were identified; therefore, no conclusions could be drawn. Link to […]

Internet-Delivered Cognitive Behavioural Therapy for Major Depressive Disorder and Anxiety Disorders: An Environmental Scan

This Environmental Scan provides information on internet-delivered cognitive behavioural therapy (iCBT) programs for major depression and anxiety disorders in Canada. It also raises awareness on considerations for the implementation of these programs. This report identified at least 15 iCBT programs that are available in various Canadian jurisdictions, and may be of interest to those exploring […]

Portable or Temporary Negative Pressure Rooms for Tuberculosis: Clinical Effectiveness and Guidelines

This Rapid Response review aimed to identify available evidence on the clinical effectiveness of portable or temporary negative pressure rooms and related evidence-based guidelines for the management of people with active tuberculosis. The review included a search for relevant studies on COVID-19 and other respiratory illnesses. As no relevant studies or guidelines on this topic […]

Quick Start: Radiology Services and COVID-19

These citations related to radiology services and COVID-19 are intended to provide a preliminary quick start to more comprehensive searching or to help frame questions or issues. If you’d like to know more, please contact CADTH via our email address or our requests page. Link to Report Quick Start: Radiology Services and COVID-19

Infection Prevention and Control Measures in Mental Health Facilities: Guidelines

CADTH conducted a Rapid Response search for evidence-based guidelines regarding infection prevention or control measures in mental health treatment facilities. No relevant evidence-based guidelines were identified; therefore, no conclusions can be drawn based on this review. Note that a list of other potentially relevant citations can be found in the report’s Appendix. Link to Report […]

Pre-Treatment Mouth Rinses for Dental Patients With Suspected SARS or COVID-19: Clinical Effectiveness and Guideline

No literature was identified regarding the clinical effectiveness of pre-dental treatment mouth rinses for patients with suspected severe acute respiratory syndrome or coronavirus disease. Additionally, no evidence-based guidelines were identified regarding the use of pre-dental treatment mouth rinses in patients with suspected severe acute respiratory syndrome or coronavirus disease. Link to Report Pre-Treatment Mouth Rinses […]

SARS-CoV-2 Longevity on and Transmission via Materials: Evidence

One non-randomized study was identified regarding the lifespan of severe acute respiratory syndrome coronavirus 2 on different materials. No clinical evidence was identified regarding severe acute respiratory syndrome coronavirus 2 transmission via materials. Link to Report SARS-CoV-2 Longevity on and Transmission via Materials: Evidence

Quick Start: Pulmonary Auscultation Without Touching or Contamination

These citations related to pulmonary auscultation without touching or contamination are intended to provide a preliminary quick start to more comprehensive searching or to help frame questions or issues. If you’d like to know more, please contact CADTH via our email address or our requests page. Link to Report Quick Start: Pulmonary Auscultation Without Touching […]