Ongoing Trials for Drugs in the Prevention and Treatment of COVID-19

This report provides information on ongoing randomized controlled trials of drugs being investigated to treat or prevent COVID-19. It will be updated every two weeks. Ongoing trials of vaccines and plasma-based therapies are addressed in separate CADTH reports. Link to Report Ongoing Trials for Drugs in the Prevention and Treatment of COVID-19 (Updated February 19, […]

Tocilizumab and Sarilumab: Evidence Review and Appraisal

Tocilizumab and sarilumab are classified as humanized monoclonal antibodies against the interleukin-6 receptor and are used in rheumatology. CADTH has conducted a Technology Review on tocilizumab and sarilumab for their potential use in managing COVID-19. Link to Report Tocilizumab and Sarilumab: Evidence Review and Appraisal

Remdesivir: Evidence Review and Appraisal

CADTH conducted a Health Technology Review on remdesivir — an antiviral drug currently being used to treat COVID-19. Remdesivir was approved in Canada on July 27, 2020 to treat adults and adolescents with severe symptoms of COVID-19 who have pneumonia and require extra oxygen. Four randomized controlled trials were identified and included in the review. […]

Respiratory Personal Protective Equipment for Female Presenting Individuals

CADTH conducted a Rapid Response Report to search for clinical evidence or evidence-based guidelines regarding the use of respiratory personal protective equipment designed specifically for female presenting individuals during COVID-19. However, no clinical evidence or evidence-based guidelines were identified. References that did not meet the inclusion criteria, but may still be of interest, were included […]

Ivermectin for the Treatment and Prevention of COVID-19

To find effective treatment for COVID-19, researchers have started studying older drugs approved for other infections or diseases. One recent drug of interest is ivermectin, a drug typically used to treat patients with parasitic infections (e.g., roundworm). This report looks at the evidence regarding ivermectin to treat patients with COVID-19 infections. While some lab studies […]

Saliva-Based Testing as an Alternative to Traditional COVID-19 Testing Techniques

This newsletter article provides an overview of saliva-based testing in the context of the COVID-19 pandemic. The article briefly explores the different types of COVID-19 tests, the potential advantages of using saliva samples for testing, the clinical evidence, and the current practice in Canada. Link to Report Saliva-Based Testing as an Alternative to Traditional COVID-19 […]

Respirator Device Fit for Individuals With Facial Hair

A properly fitted respirator device (e.g., N95 masks) is an important piece of personal protective equipment. With the COVID-19 pandemic, there is greater interest in how well filtering respirator devices fit when a person has facial hair — like a beard, moustache, or sideburns. This report looks at the evidence regarding facial hair and respirator […]