Ongoing Trials of Plasma-Based Therapies for the Treatment of COVID-19

This report provides information on ongoing randomized controlled trials of intravenous immune globulin and hyperimmune globulin that are being investigated for the management of COVID-19. It will be updated every month. Ongoing trials of convalescent plasma are addressed in separate CADTH reports Link to Report Ongoing Trials of Plasma-Based Therapies for the Treatment of COVID-19 […]

COVID-19 mRNA Vaccines for People With Cancer

The first two vaccines (both messenger ribonucleic acid — mRNA — vaccines) for the prevention of COVID-19 disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been authorized for emergency use. People with cancer are at a higher risk for serious illness resulting from COVID-19, but were not specifically included in the trials […]

Rapid Point-of-Care Testing for COVID-19

This CADTH Horizon Scan describes how rapid point-of-care screening tests for COVID-19 are being used in Canada and internationally. It also reports on evidence regarding their effectiveness on COVID-19 transmission (no studies identified) and performance. The scan identifies guidance documents that provide suggestions for use in specific settings and populations. Link to Report Rapid Point-of-Care […]

Serological Tests for COVID-19

If accurate, antibody-based serology tests may provide information on who has COVID-19 or who has been infected. Health Canada is actively assessing these tests within the expedited access process. However, to date, the performance and role of these tests in clinical settings has not been completely demonstrated. Currently, evidence to confirm that individuals have immunity […]

Virus-neutralizing monoclonal antibodies against SARS-CoV-2

This Horizon Scan explores what we know about virus-neutralizing monoclonal antibodies, their mechanism of action and how they are administered, and which virus-neutralizing monoclonal antibodies are in clinical development for SARS-CoV-2 infection. Link to Report CADTH Emerging Health Technology for COVID-19: Virus-Neutralizing Monoclonal Antibodies Against SARS-CoV-2  

COVID-19 Testing: A Summary of Testing Methods

This report provides an overview of testing methods for COVID-19. A description of published clinical evidence and important considerations related to the potential implementation of these tests are provided. As demands for testing during the pandemic increases, this information may be of interest to health care decision-makers interested in learning more about the availability and […]

COVID-19 Impact on Intimate Partner Violence and Child Maltreatment

This report provides an overview of the evidence regarding the impact of COVID-19 and related restrictions on intimate partner violence and child maltreatment. The report also includes information on risk factors for violence, access to support for those at risk, and measures to mitigate the risk of intimate partner violence and child maltreatment during this […]

Quick Start: Public Health Interventions for the Prevention of COVID-19 in Schools: Guidelines

These citations related to public health interventions and prevention of COVID-19 in schools are intended to provide a preliminary quick start to enable more comprehensive searching, or to help frame questions or issues. Overall, three evidence-based guidelines were identified. If you would like to know more, please contact CADTH by email or via our requests […]

Convalescent Plasma Therapy for the Treatment of COVID-19 : A Review of Clinical Effectiveness

Convalescent plasma (CP) therapy is an intervention where plasma is collected from recovered COVID-19 patients in the hope that the disease-specific antibodies could help the recipient recover from COVID-19. Evidence on the effectiveness of CP therapy for the treatment of COVID-19 is still in the early stages. This report summarizes the current evidence and it […]