Gabapentin, Phenobarbital, Diazepam, and Lorazepam for the Treatment of Alcohol Withdrawal: Clinical Effectiveness and Guidelines

During pandemics, such as the COVID-19 pandemic, it can be challenging to offer care to vulnerable populations, especially those experiencing alcohol withdrawal. CADTH conducted a Rapid Response on the clinical effectiveness of using gabapentin, phenobarbital, diazepam, or lorazepam to treat alcohol withdrawal. This report also searched for evidence-based guidelines for treating alcohol withdrawal in the […]

Convalescent Plasma Therapy for the Treatment of COVID-19 : A Review of Clinical Effectiveness

Convalescent plasma (CP) therapy is an intervention where plasma is collected from recovered COVID-19 patients in the hope that the disease-specific antibodies could help the recipient recover from COVID-19. Evidence on the effectiveness of CP therapy for the treatment of COVID-19 is still in the early stages. This report summarizes the current evidence and it […]

Remdesivir: Evidence Review and Appraisal

CADTH conducted a Health Technology Review on remdesivir, an antiviral drug currently being used to treat COVID-19. Presently, remdesivir is not approved in Canada and access to it is limited to clinical trials. Four randomized controlled trials were identified (two completed and two ongoing) in the review; however, due to insufficient published evidence, the potential […]

Virtual Pulmonary Rehabilitation for Respirator Disease or Post-Intensive Care Syndrome: Clinical Effectiveness and Guidelines

As a result of the COVID-19 pandemic, many people are interested in whether health care interventions can be done virtually or remotely. CADTH conducted a Rapid Response regarding virtual pulmonary rehabilitation (programs to improve lung function) for patients with respiratory disease or post-intensive care syndrome (health problems individuals may experience after being in intensive care). […]

Venous Thromboembolism Prophylaxis in Patients Hospitalized With COVID-19

Patients hospitalized with COVID-19, particularly those in intensive care units, are at an increased risk for venous thromboembolism (VTE). CADTH’s Horizon Scan identified seventeen studies reporting on the frequency of VTE in patients hospitalized with COVID-19. The Horizon Scan also summarized Canadian and International guidance regarding the dose and duration of pharmacologic thromboprophylaxis for VTE […]

Quick Start: Aerosol Generating Medical Procedures

These citations related to aerosol generating medical procedures are intended to provide a preliminary quick start to enable more comprehensive searching, or to help frame questions or issues. If you’d like to know more, please contact CADTH by email or our requests page. Link to Report Quick Start: Aerosol Generating Medical Procedures  

Influenza Vaccination and Risk of Subsequent Non-Influenza Respiratory Viruses: Safety

This CADTH Rapid Response Report looks at evidence on the safety of influenza vaccination in terms of the risk of contracting subsequent non-influenza respiratory viruses. This information might help inform decisions on the administration of the seasonal flu vaccine during the COVID-19 pandemic. Three non-randomized studies were identified. Two found no association between the influenza […]

Health Technology Update, Issue 27

This issue of Health Technology Update features brief summaries of information on a range of technologies that aim to support the prevention, identification, and management of COVID-19 — from smartphone apps for contact tracing to self-collected sampling for diagnostic testing. These technologies were identified through the CADTH Horizon Scanning Service as topics of potential interest […]

Quick Start: Pandemic Staffing Allocation

These citations related to pandemic staffing allocation are intended to provide a preliminary quick start to enable more comprehensive searching, or to help frame questions or issues. If you’d like to know more, please contact CADTH by email or our requests page. Link to Report Quick Start: Pandemic Staffing Allocation